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The results of the trial could answer whether carboplatin hypersensitivity patients have similar chemo-responses in non-platinum regimens without compromising the efficacy of the antineoplastic regimens of these patients. The annual ESMO Congress is the most prestigious and influential oncology platform in Europe and is the ideal place to learn about the latest science, network with colleagues and keep pace with today's rapid developments in cancer research. This patient developed hypersensitivity reactions during her 23rd cycle of carboplatin administration at a cumulative dose of approximately 14,000 mg. She experienced skin rash, tachycardia, and dyspnea 13 min after starting the infusion. Our findings also suggest that a history of drug or food allergies is a predictive factor for carboplatin-related hypersensitivity. Pediatric. We retrospectively recruited all women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with single-agent carboplatin or a carboplatin-based combination chemotherapy regimen at National Taiwan University Hospital from January 2006 to December 2013. Among these 75 women, 16 (21.3%) experienced severe hypersensitivity reactions (grades 3 and 4). FOIA Upon the occurrence of symptoms and signs, carboplatin infusion was immediately stopped. doi: 10.1007/s10147-014-0731-1. (2009). Summary format including algorithms, figures andtables for your presentations. (2003). The cumulative incidence of severe carboplatin-related hypersensitivity was 1% after 15 cycles and 2% after 24 cycles, with a plateau beyond this cycle number, and 1% at >7,500 mg and 2% at >12,500 mg, with a plateau beyond this dose (Figures 1A,B). Unauthorized use of these marks is strictly prohibited. Atopic patients are at increased risk for chemotherapy and MoAbs drug allergy and the current patterns of treatment with recurrent and intermittent drug exposures may favor the development of drug allergies. 2023 Jan 23;11(2):252. doi: 10.3390/vaccines11020252. Anaphylaxis and hypersensitivity in trials of intravenous pertuzumab 2017 Jul 1;28(suppl_4):iv119-iv142. Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. Clinical analysis of thirteen cases of hypersensitivity reactions to carboplatin. Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines (2017) 8 Pager Instructions Coverage Begins March 1, 2019 Coverage Ends: TBD 1. . Br. Front Oncol. Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: a brief report. Cancer Sci. EHA Endorsement of ESMO Clinical Practice Guidelines for Diagnosis, Treatment, and Follow-up for Myelodysplastic Syndromes. The dilemma of carboplatin-associated hypersensitivity reactions in ovarian cancer management. Management of infusion reactions to systemic anticancer therapy: ESMO J Exp Clin Cancer Res (2011) 30:93.10.1186/1756-9966-30-93 Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. 2014;24(2):72-9; quiz 2 p following 79. The .gov means its official. 'Allergy' is a hypersensitivity reaction (HSR) initiated by specic immunolo- gical mechanisms. The ESMO Clinical Practice Guidelines (CPGs) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings of evidence-based medicine. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. This site uses cookies. We retrieved clinical information, including age, menopausal status, cancer stage, surgical findings, chemotherapeutic treatment history, recurrence status, and survivorship, from the clinical and operative notes and discharge summaries stored in a centralized database. Met Based Drugs (2010) 2010 Available from: Markman M. Toxicities of the platinum antineoplastic agents. Res. doi: 10.1111/IGC.0b013e3181a1bf2e, Ledermann, J. Chan. doi: 10.1093/annonc/mdy158. These ESMO Clinical Practice Guidelines provide recommendations on the prevention/management of dermatological toxicities. (2006). Symptoms and signs of 75 patients with hypersensitivity reactions to carboplatin. Monitor. This site uses cookies. A. We also provide recommendations for the continuation of treatment in ovarian cancer patients. All funding for this site is provided directly by ESMO. Supportive and Palliative Care | ESMO J. Clin. Create your own personalised agenda and browse the complete scientific programme by day, topic, cancer type and track with the ESMO events app. and transmitted securely. Monitor. Algorithm for the evaluation of drug hypersensitivity reactions and the role of desensitization for the re-introduction of the first-line medications, when no alternative is available or the alternative does not provide the same benefits or life expectancy as the first line. This was the largest series of gynecological malignancies investigated for carboplatin-related hypersensitivity reactions. 44, 837840. Does the platinum-free interval predict the incidence or severity of hypersensitivity reactions to carboplatin? Carboplatin hypersensitivity: evaluation and successful desensitization protocol. Only 2 women are Mongolians and the other 733 women are Asian Taiwanese. PH IV/PH FDC SC for HER2-positive BC were well tolerated, with few grade 3 anaphylaxis/hypersensitivity events reported with PH IV and no grade 3 related events with PH FDC SC. Challenges in the Development of Intravenous Neurokinin-1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose-Finding, Phase1 Study of Intravenous Fosnetupitant. also successfully developed a platinum desensitization protocol for patients with either a positive carboplatin skin test or a history of prior carboplatin hypersensitivity (Altwerger et al., 2017). National Library of Medicine Disclaimer. Acquisition of data: Y-HT, S-PL, Y-CC, Y-LC. Nektaria M, Ekaterini S, Ioannis K, Leonidas M, Muhammad Wasif S. Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review. Read guidelines by topic Latest Guidelines News This Webinar series brings together all the relevant stakeholders who are developing each guideline, as well as those who are consulting and implementing the guideline. Patients with prior drug or food allergies should be closely monitored during carboplatin administration. Invest. Expert Perspectives: ESMO 2017 Changes Lung Cancer Practice Authors: S. Rosell, I. Blasco, L. Garca Fabregat, A. Cervantes and K. Jordan In 74 of the 75 patients, the hypersensitivity reactions subsided within several minutes to several hours after onset, and the patients recovered without any sequelae. (33)]. 2017;40(3):120-127. doi: 10.1159/000458443. PDF Hypersensitivity & Infusion Reaction Management - Stephenson Cancer Center However, prolonged carboplatin use is associated with an increased incidence of carboplatin-related hypersensitivity reactions (Markman et al., 1999; Wang et al., 2009). doi: 10.1007/s00520-011-1123-y, Gomez, R., Harter, P., Lck, H. J., Traut, A., Kommoss, S., Kandel, M., et al. The rate of hypersensitivity was significantly higher among patients with advanced stage disease (IIIIV) compared to patients with early stage disease (III) (P < 0.001, Kruskal-Wallis test), and among patients with serous or mixed histological type compared to patients with other histological types (P = 0.003, Kruskal-Wallis test). This study was approved by the Research Ethics Committee at the National Taiwan University Hospital (201706023RINC). Tamiya, M., Kuhara, H., Hirashima, T., Kondo, Y., Santo, M., Morishita, N., et al. Bethesda, MD 20894, Web Policies doi: 10.1200/JCO.2006.06.0913, Polyzos, A., Tsavaris, N., Kosmas, C., Arnaouti, T., Kalahanis, N., Tsigris, C., et al. Similarly, Kandel et al. WHIPPANY, N.J., Sept. 1, 2017 /PRNewswire/ -- Bayer will present the latest research from across its growing oncology portfolio at the European Society for Medical Oncology (ESMO) 2017 Congress . J. Gynecol. We assessed occurrence, incidence and severity of these events in key Roche clinical trials of PH IV/PH FDC SC, and did a timetrend analysis (by cycle) for metastatic BC (MBC) and early BC (EBC) studies. 3, 10 In subsequent trials, 11 - 16 patients were premedicated (2003). EHA Endorsement of ESMO Clinical Practice Guidelines for Dia - LWW The comparison between other countries and ours about characteristics of the patients receiving carboplatin-based chemotherapy and risk factors of carboplatin-related hypersensitivity reactions. BRCA1/2 mutation has been reported to correlate with carboplatin hypersensitivity (Altwerger et al., 2017). doi: 10.1159/000055363, Pujade-Lauraine, E., Wagner, U., Aavall-Lundqvist, E., Gebski, V., Heywood, M., Vasey, P. A., et al. Incidence of carboplatin-related hypersensitivity reactions in Japanese patients with gynecologic malignancies. 107, 163165. eCollection 2022. Int. Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: The Role of Desensitizations Front Immunol. Table 4. All funding for this site is provided directly by ESMO. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. Our present findings confirmed these factors and identified other risk factors, including advanced disease, serous histology, and the presence of malignant ascites. Check the latest publications and updates here to make sure you dont miss anything. 8:800. doi: 10.3389/fphar.2017.00800. Putative mechanism of protection against anaphylaxis during human desensitizations. Recently, more and more patients with ovarian cancer have been receiving genetic counseling and testing, including BRCA1/2 and the other heterologous recombinant deficient (HRD) genes, because of the development of PAPP inhibitors. The tests were analyzed at an accredited lab according to protocol. doi: 10.1111/j.1525-1438.2005.00136.x, Koshiba, H., Hosokawa, K., Kubo, A., Miyagi, Y., Oda, T., Miyagi, Y., et al. Integrating science into oncology for a better patient outcome, ESMO Designated Centres Community Session, Create your own personalised agenda and browse the complete scientific programme by day, topic, cancer type and track with the. Clinical features and management of carboplatin-related hypersensitivity reactions in pediatric low-grade glioma. Do Steroids Matter? A Retrospective Review of Premedication for Taxane 2018 Oct 1;29(Suppl 4):iv260. Pharmacol. (2005). 2011 Aug;12(8):806-14. doi: 10.1016/S1470-2045(10)70208-4. This exciting partnership delivered a unique cancer congress in Europe with huge scientific reach and the true potential to improve the lives of cancer patients. ESMO 2017 Congress | Madrid, Spain | Oncology Conferences We invite ESMO members and event attendees to view the 2017 webcasts and presentations using the link below. doi: 10.1093/annonc/mdx216. The independent sample t-test was used to evaluate how carboplatin cycle and dose correlated with the incidence of hypersensitivity and severe hypersensitivity reactions. Epub 2022 Oct 20. http://downloads.hindawi.com/journals/mbd/2010/207084.pdf, Kadoyama K, Kuwahara A, Yamamori M, Brown JB, Sakaeda T, Okuno Y. Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA adverse event reporting system, AERS. 2017 Jun 20;18(6):1316. doi: 10.3390/ijms18061316. Risk factors for these reactions included advanced disease, serous histological type, malignant ascites, and history of drug allergies. Here, we retrospectively evaluated carboplatin-related hypersensitivity reactions among patients with gynecological cancer (ovarian, fallopian tube, or primary peritoneal cancer) who received carboplatin-containing regimens at a single medical institute in Taiwan. Oncol Res Treat. Supporting your clinical decisions with ESMOs regularly updated Clinical Practice Guidelines and consensus recommendations, developed by the leading experts in our profession. Allergy Asthma Proc (2011) 32(1):79.10.2500/aap.2011.32.3409 We analyzed the incidence, characteristics, risk factors, management, and outcomes of carboplatin-related hypersensitivity reactions among these patients. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. A total of 59 women experienced mild signs and symptoms (grades 1 and 2), including skin rash (69.3%), skin itching (64.0%), facial flushing (56.0%), dyspnea (41.3%), chest pain (25.3%), tachycardia (18.7%), paresthesias (16.0%), abdominal cramping (13.3%), and diaphoresis (12.0%). Multivariate analysis was conducted using logistic regression to estimate the association between the potential risk factors and the occurrence of hypersensitivity. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. Lacouture, V. Sibaud, P.A. Evaluating whether any factors can predict carboplatin hypersensitivity, we identified a high correlation with the carboplatin cycle and cumulative dose (Pearson correlation coefficient 0.9318). S M S, Naveen NR, Rao GK, Gopan G, Chopra H, Park MN, Alshahrani MM, Jose J, Emran TB, Kim B. DARMSTADT, Germany, August 31, 2017 /PRNewswire/ --Not intended for U.K. or U.S. based media ESMO 2017 abstract #Erbitux: 576P, 593P, 1068P, 1579. Analysis of the pattern of hypersensitivity reactions in patients receiving carboplatin retreatment for recurrent ovarian cancer. The total incidence of carboplatin-related hypersensitivity was 3.21% by the cycle of carboplatin. doi: 10.1016/j.ygyno.2007.06.016, Markman, M., Kennedy, A., Webster, K., Elson, P., Peterson, G., Kulp, B., et al. Gerber, C. van den Hurk, P. Fernndez-Peas, D. Santini, F. Jahn, K. Jordanon behalf of the ESMO Guidelines Committee. There is evidence that inhibitory mechanisms blocking IgE/antigen mast cell activation are active during desensitization, enhancing safety. Cancer 109, 10721078. However, severe carboplatin-related hypersensitivity symptoms can be fatal, as in one of our cases. Utilizing Biologics in Drug Desensitization. Vaccines (Basel). Furthermore, patients with carboplatin hypersensitivity had a higher incidence of previous allergic history to other cytotoxic drugs, including gemcitabine, paclitaxel, and doxorubicin, compared to those without (12/75 vs. 30/660, P < 0.001, chi-squared test; Table 7). Skin Testing and Basophil Activation Testing Is Useful for Assessing Immediate Reactions to Polyethylene Glycol-Containing Vaccines. doi: 10.1200/JCO.2003.02.153, Parmar, M. K., Ledermann, J. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23, Published in 2020 Ann Oncol (2020)Authors:M.E. Drafting of manuscript: Y-HT and W-FC. In the late 1980s, more than a dozen phase I studies analyzed the efficacy of paclitaxel as a single agent. The BRCA status of our patients was not available for further analysis in this retrospective study. Necessary cookies enable core functionality. Supportive. 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Management of infusion reactions to systemic anticancer therapy: ESMO Report of three cases. The annual incidence of carboplatin-related hypersensitivity reactions in 735 women with ovarian, fallopian tube, or primary peritoneal cancers. PMC Epub 2017 Feb 24. A., Raja, F. A., Fotopoulou, C., Gonzalez-Martin, A., Colombo, N., Sessa, C., et al. The yearly incidence of carboplatin-related hypersensitivity gradually increased from 0.88 in 2006 to 5.42% in 2013 (Table 1), in association with increased use of carboplatin. The incidence of carboplatin-related hypersensitivity was higher in patients with advanced stage disease (P < 0.001, Kruskal-Wallis test), serous and mixed histological types (P = 0.003, Kruskal-Wallis test), malignant ascites (P = 0.009, chi-square test), and history of other drug allergy (P < 0.001, chi-square test). For more detailed information on the cookies we use, please check our Privacy Policy. 8600 Rockville Pike The incidence of carboplatin-related hypersensitivity correlated with cycle number and dose, with the first episode occurring at a median of 12 cycles and 6,816 mg. Oncol. 2022 May 20;12:879391. doi: 10.3389/fonc.2022.879391. Clinical Practice Guidelines on Supportive Care - ESMO Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic However, 48 (78.7%) of these patients developed repeated hypersensitivity reactions, even after pre-treatment with intravenous antihistamines, H2 blocker, and corticosteroids prior to carboplatin re-administration. Received: 23 July 2017; Accepted: 23 October 2017; Published: 06 November 2017. Thus, the risk of severe carboplatin-related hypersensitivity may influence its usage in gynecological cancers, and it is important to develop protocols to reduce this risk, especially the risk of severe reactions. Our results revealed carboplatin-related hypersensitivity reactions in 1 out of 10 women treated with a carboplatin-containing regimen for ovarian, fallopian tube, or primary peritoneal cancer. J. Clin. In conclusion, in our present population of women with gynecological malignancies treated with platinum-based chemotherapy, 1 in 10 developed carboplatin-related hypersensitivity reactions. (2011). The ESMOClinical Practice Guidelines(CPGs) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings ofevidence-based medicine. Cancer 19, 12841287. We also recorded the procedures applied to treat the hypersensitivity reactions and efforts to manage the side effects of carboplatin administration. Genc et al. eCollection 2017. We analyzed the relationships among the incidence, characteristics, risk factors, management, and outcomes of carboplatin-related hypersensitivity reactions in this patient population. Classical and new chemotherapy drugs, monoclonal antibodies (MoAbs), and small molecules to treat cancer and chronic inflammatory diseases are aimed at improving quality of life and life expectancy of patients, but an increasing number of reactions including anaphylaxis precludes their use in targeted populations. ESMO Virtual Congress 2020 | OncologyPRO Request PDF | On Jul 13, 2017, Susana Rosell Kernen published Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines | Find, read and cite all the . (2009). Oncol. eCollection 2022 Apr. (Moon et al., 2013) BRCA1/2 mutation patients had early-onset carboplatin hypersensitivity at a lower cumulative exposure. Int. -. Tumori 89, 311313. Most IRs are mild with symptoms such as chills, fever, nausea, headache, skin rash, pruritus, etc. Support for third-party writing assistance for this abstract, furnished by Alison McGonagle, PhD, of Health Interactions, was provided by F. Hoffmann-La Roche Ltd., Basel, Switzerland. Emetogenicity of Chemotherapy : MASCC/ESMO Guidelines - EMJ Death from anaphylaxis to cisplatin: a case report. Educate. *Correspondence: Wen-Fang Cheng, wenfangcheng@yahoo.com, Creative Commons Attribution License (CC BY). Pegylated liposomal doxorubicin and carboplatin compared with paclitaxel and carboplatin for patients with platinum-sensitive ovarian cancer in late relapse. Methods. reported that the majority (93%) of patients with a BRCA1/2 mutation develop carboplatin hypersensitivity, and that BRCA1/2 mutation is an independent risk factor for the development of carboplatin hypersensitivity. A three-step method was developed to identify hypersensitivity reactions, including anaphylaxis, in a clinical trial database and could be applied to investigational drugs to improve early detection and monitoring of potential safety concerns, subsequent patient safety management strategies, and potentially programme-wide drug development The https:// ensures that you are connecting to the The drug or food allergy in 735 patients receiving carboplatin-based chemotherapy. Patients feel psycho-social impact of chemo m | EurekAlert! Among the 651 women (88.6%) diagnosed with ovarian cancer, 474 (64.5%) had stage IIIIV disease.
Former Fox 6 Milwaukee Meteorologists, Massena Police Blotter, Articles E
Former Fox 6 Milwaukee Meteorologists, Massena Police Blotter, Articles E